DegronMD - O43167(ZBTB24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q669R	TCGA-95-7039	LUAD	TCGA	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.2222
p.Q669R	DO23907	LUAD	ICGC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.2222
p.S665P	TCGA-A5-A0G2	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.6752
p.S665P	DO41235	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.6752
p.A668V	TCGA-A8-A093	BRCA	TCGA	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.25
p.A668V	DO4161	BRCA	ICGC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.25
p.T655I	TCGA-F7-A624	HNSC	TCGA	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.1667
p.T655I	DO44440	HNSC	ICGC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.1667
p.A668T	DO233750	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.25
p.A668T	ACH-000988	Endometrial/Uterine Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.25
p.A668T	MFE-319	endometrium	COSMIC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.25
p.T655A	DO233780	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation rewiring degron network	0.1667
p.T662I	ACH-001125	Brain Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.5966
p.T662I	MOG-G-CCM	central nervous system	COSMIC	ATSTS	DEG_SPOP_SBC_1	661:665	Mutation altering degron motif	0.5966

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons