DegronMD - O43298(ZBTB43)

FUNCTION: May be involved in transcriptional regulation.

GO - Biological processes (BP): regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase III general transcription initiation factor binding [GO:0001025]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PSSSS	DEG_SPOP_SBC_1	SPOP	Zinc finger and BTB domain-containing protein 43	143:147	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P143Q	TCGA-D3-A2JB	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7035
p.P143Q	DO47607	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation altering degron motif	0.7035
p.N149K	TCGA-77-7465	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.N149K	DO27699	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2778
p.G150C	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.25
p.G150C	ACH-000852	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.25
p.G150C	NCI-H1435	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.25
p.L151V	SIDM00155	Head and Neck Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2222
p.L151V	SIDM00670	Pancreatic Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2222
p.D139N	SIDM00864	Cervical Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2222
p.D139N	ACH-001341	Cervical Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2222
p.D139N	DoTc2-4510	cervix	COSMIC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.2222
p.H136Y	TCGA-EE-A2GO	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.H136Y	DO37823	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1389
p.N135S	TCGA-MI-A75G	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111
p.N135S	DO49709	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	143:147	Mutation rewiring degron network	0.1111

Showing 1 to 16 of 16 entries

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for ZBTB43 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB43

UniProt ID: O43298

Entrez ID: 23099

Protein name: Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x)

External links: UniprotKB HGNC RefSeq COSMIC

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for ZBTB43 in