DegronMD - O43541(SMAD6)

SMAD6

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R285C	TCGA-BR-6452	STAD	TCGA	PPPY	ITCH	276:279	Mutation rewiring degron network	0.1667
p.R285C	DO38404	STAD	ICGC	PPPY	ITCH	276:279	Mutation rewiring degron network	0.1667
p.Y288C	TCGA-BR-6452	STAD	TCGA	PPPY	ITCH	276:279	Mutation rewiring degron network	0.0833
p.Y288C	DO38404	STAD	ICGC	PPPY	ITCH	276:279	Mutation rewiring degron network	0.0833
p.P276S	TCGA-DA-A1I0	SKCM	TCGA	PPPY	ITCH	276:279	Mutation altering degron motif	0.6752
p.P276S	DO37719	SKCM	ICGC	PPPY	ITCH	276:279	Mutation altering degron motif	0.6752
p.P278L	TCGA-EE-A2GC	SKCM	TCGA	PPPY	ITCH	276:279	Mutation altering degron motif	0.6471
p.P278L	DO37839	SKCM	ICGC	PPPY	ITCH	276:279	Mutation altering degron motif	0.6471
p.E287D	DO229018	LICA	ICGC	PPPY	ITCH	276:279	Mutation rewiring degron network	0.1111
p.R285H	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	276:279	Mutation rewiring degron network	0.1667
p.R285H	NCI-H650	lung	COSMIC	PPPY	ITCH	276:279	Mutation rewiring degron network	0.1667
p.Y288N	ACH-000450	Skin Cancer	CCLE	PPPY	ITCH	276:279	Mutation rewiring degron network	0.0833
p.P275L	ACH-001767	Non-Cancerous	CCLE	PPPY	ITCH	276:279	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc