DegronMD - O43561(LAT)

FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin e... View more >>

GO - Biological processes (BP): adaptive immune response [GO:0002250]; calcium-mediated signaling [GO:0019722]; gene expression [GO:0010467]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; lymphocyte homeostasis [GO... View more >>

GO - Molecular function (MF): protein kinase binding [GO:0019901]; signaling receptor complex adaptor activity [GO:0030159]

GO - Cellular component (CC): cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; Golgi apparatus [GO:0005794]; immunological synapse [GO:0001772]; integral component of membrane [GO:0016021]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A170T	DO42713	UCEC	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7139
p.A170T	DO42713	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7139
p.L61M	SIDM00683	Prostate Carcinoma	GDSC	PPAY	ITCH	61:64	Mutation altering degron motif	0.711
p.L61M	LNCaP-Clone-FGC	prostate	COSMIC	PPAY	ITCH	61:64	Mutation altering degron motif	0.711
p.P173T	ACH-001408	Bladder Cancer	CCLE	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7031
p.P173T	ACH-001408	Bladder Cancer	CCLE	PATST	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7031
p.V170L	TCGA-DF-A2KU	UCEC	TCGA	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.6765
p.V170L	TCGA-DF-A2KU	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.6765
p.A183V	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.A156V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation blocking phosphorylation signal	0.5
p.A156V	ACH-000942	Leukemia	CCLE	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation blocking phosphorylation signal	0.5
p.L184R	HEC-1	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5
p.A183V	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation blocking phosphorylation signal	0.5
p.A60T	TCGA-BR-8591	STAD	TCGA	PPAY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.P65T	DO3822	BRCA	ICGC	PPAY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.P165R	DO233262	GACA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.3056
p.A176S	DO229041	LICA	ICGC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2778
p.A176S	DO229041	LICA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.25
p.A178T	TCGA-EO-A22R	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222
p.E178K	CRO-AP3	NS	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 35 entries

Previous1 2Next

Kaplan plot for LAT in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAT

UniProt ID: O43561

Entrez ID: 27040

Protein name: Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LAT in