DegronMD - O43561(LAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A60T	TCGA-BR-8591	STAD	TCGA	PPAY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.V170L	TCGA-DF-A2KU	UCEC	TCGA	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.6765
p.V170L	TCGA-DF-A2KU	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.6765
p.A178T	TCGA-EO-A22R	UCEC	TCGA	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1944
p.A178T	TCGA-EO-A22R	UCEC	TCGA	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222
p.R53Q	DO552	BLCA	ICGC	PPAY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.P65T	DO3822	BRCA	ICGC	PPAY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.H55Y	DO222765	COCA	ICGC	PPAY	ITCH	61:64	Mutation rewiring degron network	0.1667
p.P165R	DO233262	GACA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.3056
p.P165R	DO233262	GACA	ICGC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.A176S	DO229041	LICA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.25
p.A176S	DO229041	LICA	ICGC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2778
p.P158L	DO222420	MELA	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.A170T	DO42713	UCEC	ICGC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7139
p.A170T	DO42713	UCEC	ICGC	PATST	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7139
p.L61M	SIDM00683	Prostate Carcinoma	GDSC	PPAY	ITCH	61:64	Mutation altering degron motif	0.711
p.L61M	LNCaP-Clone-FGC	prostate	COSMIC	PPAY	ITCH	61:64	Mutation altering degron motif	0.711
p.A156V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation blocking phosphorylation signal	0.5
p.A156V	ACH-000942	Leukemia	CCLE	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation blocking phosphorylation signal	0.5
p.P173T	ACH-001408	Bladder Cancer	CCLE	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7031
p.P173T	ACH-001408	Bladder Cancer	CCLE	PATST	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7031
p.E179K	CRO-AP3	NS	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1667
p.E179K	CRO-AP3	NS	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.A181V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.A181V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T56M	PCI-15A	upper aerodigestive tract	COSMIC	PPAY	ITCH	61:64	Mutation rewiring degron network	0.1944
p.E178K	CRO-AP3	NS	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1944
p.E178K	CRO-AP3	NS	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222
p.L184R	HEC-1	endometrium	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5
p.A180V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1389
p.A180V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.A182V	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.0833
p.A182V	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.A183V	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PDSTPATS	DEG_SCF_FBW7_1	166:173	Mutation blocking phosphorylation signal	0.5
p.A183V	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for LAT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAT

UniProt ID: O43561

Entrez ID: 27040

Protein name: Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAT in