DegronMD - O43760(SYNGR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P220L	TCGA-CD-8528	STAD	TCGA	PPVY	ITCH	221:224	Mutation rewiring degron network	0.3056
p.P220L	SIDM02039	Colorectal Carcinoma	GDSC	PPVY	ITCH	221:224	Mutation rewiring degron network	0.3056
p.E216K	TCGA-EC-A24G	UCEC	TCGA	PPVY	ITCH	221:224	Mutation rewiring degron network	0.1944
p.E216K	TCGA-XF-AAN0	BLCA	TCGA	PPVY	ITCH	221:224	Mutation rewiring degron network	0.1944
p.E216K	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	221:224	Mutation rewiring degron network	0.1944
p.A212V	TCGA-FI-A2D5	UCEC	TCGA	PPVY	ITCH	221:224	Mutation rewiring degron network	0.0833
p.G217S	TCGA-RP-A693	SKCM	TCGA	PPVY	ITCH	221:224	Mutation rewiring degron network	0.2222
p.T219I	DO225339	BRCA	ICGC	PPVY	ITCH	221:224	Mutation rewiring degron network	0.2778
p.R216Q	DO49954	CESC	ICGC	PPVY	ITCH	221:224	Mutation rewiring degron network	0.1944
p.T222M	DO227549	COCA	ICGC	PPVY	ITCH	221:224	Mutation altering degron motif	0.7423
p.R216L	DO228971	LICA	ICGC	PPVY	ITCH	221:224	Mutation rewiring degron network	0.1944
p.P221H	DO43698	UCEC	ICGC	PPVY	ITCH	221:224	Mutation altering degron motif	0.7694
p.T211M	DO42280	UCEC	ICGC	PPVY	ITCH	221:224	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons