DegronMD - O43815(STRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D129Y	TCGA-66-2756	LUSC	TCGA	PPSY	ITCH	132:135	Mutation rewiring degron network	0.25
p.D136N	TCGA-EO-A22U	UCEC	TCGA	PPSY	ITCH	132:135	Mutation rewiring degron network	0.3056
p.T143I	DO228950	LICA	ICGC	PPSY	ITCH	132:135	Mutation blocking phosphorylation signal	0.5556
p.P135T	DO228976	LICA	ICGC	PPSY	ITCH	132:135	Mutation altering degron motif	0.7031
p.Q145R	DO47981	STAD	ICGC	PPSY	ITCH	132:135	Mutation rewiring degron network	0.0556
p.D124N	DO43755	UCEC	ICGC	PPSY	ITCH	132:135	Mutation rewiring degron network	0.1111
p.Y135C	SIDM01114	Non-Cancerous	GDSC	PPSY	ITCH	132:135	Mutation altering degron motif	0.8198
p.Y135C	ACH-001383	Prostate Cancer	CCLE	PPSY	ITCH	132:135	Mutation altering degron motif	0.8198
p.Y135C	PWR-1E	prostate	COSMIC	PPSY	ITCH	132:135	Mutation altering degron motif	0.8198
p.Y123C	PWR-1E	prostate	COSMIC	PPSY	ITCH	132:135	Mutation rewiring degron network	0.0833
p.S139N	HCC2998	large intestine	COSMIC	PPSY	ITCH	132:135	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons