DegronMD - O60248(SOX15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E33D	TCGA-A6-6781	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.E33D	DO8447	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1389
p.A171T	DO222427	BTCA	ICGC	PPSY	ITCH	165:168	Mutation rewiring degron network	0.25
p.P17L	DO227549	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1944
p.G160S	DO234391	ESAD	ICGC	PPSY	ITCH	165:168	Mutation rewiring degron network	0.1944
p.P165H	DO228986	LICA	ICGC	PPSY	ITCH	165:168	Mutation altering degron motif	0.7694
p.P157Q	DO229035	LICA	ICGC	PPSY	ITCH	165:168	Mutation rewiring degron network	0.1111
p.W12L	DO229211	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.P16L	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1667
p.S24A	SIDM01652	Non-Cancerous	GDSC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.S24A	SIDM00187	Kidney Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7588
p.R32Q	SIDM00849	Kidney Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.1667
p.S25P	SIDM01617	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.6752
p.S25P	ACH-000994	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.6752

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons