DegronMD - O60264(SMARCA5)

FUNCTION: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12434153, PubMed:28801535, PubMed:12198550, PubMed:12972596, PubMed:23911928). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250|UniProtKB:Q91ZW3, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:28801535}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D718Y	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	718:720	Mutation altering degron motif	0.7325
p.D718Y	DO41235	UCEC	ICGC	DYR	CBL_MET	718:720	Mutation altering degron motif	0.7325
p.K722Q	TCGA-AA-3984	COAD	TCGA	DYR	CBL_MET	718:720	Mutation rewiring degron network	0.2778
p.K722Q	DO9002	COAD	ICGC	DYR	CBL_MET	718:720	Mutation rewiring degron network	0.2778
p.R144H	TCGA-AJ-A3BG	UCEC	TCGA	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144H	DO33091	PACA	ICGC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144H	DO42633	UCEC	ICGC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144H	SIDM01519	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R142Q	TCGA-AP-A1E0	UCEC	TCGA	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7329
p.R142Q	TCGA-AX-A0J0	UCEC	TCGA	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7329
p.R142Q	TCGA-D1-A16Y	UCEC	TCGA	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7329
p.R142Q	DO43154	UCEC	ICGC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7329
p.R142Q	DO41133	UCEC	ICGC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7329
p.R142Q	DO41524	UCEC	ICGC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7329
p.V711I	TCGA-AX-A05Z	UCEC	TCGA	DYR	CBL_MET	718:720	Mutation rewiring degron network	0.1389
p.V711I	DO40884	UCEC	ICGC	DYR	CBL_MET	718:720	Mutation rewiring degron network	0.1389
p.N713T	TCGA-AX-A05Z	UCEC	TCGA	DYR	CBL_MET	718:720	Mutation rewiring degron network	0.1944
p.N713T	DO40884	UCEC	ICGC	DYR	CBL_MET	718:720	Mutation rewiring degron network	0.1944
p.R142G	TCGA-AX-A06J	UCEC	TCGA	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7568
p.R142G	DO43009	UCEC	ICGC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7568
p.R144C	TCGA-CM-6171	COAD	TCGA	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144C	DO8151	COAD	ICGC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144C	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144C	SIDM00461	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144C	SIDM01519	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144S	TCGA-EE-A184	SKCM	TCGA	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.R144S	DO47442	SKCM	ICGC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.Q133H	TCGA-F5-6814	READ	TCGA	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.1389
p.Q133H	DO36556	READ	ICGC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.1389
p.E149D	DO228974	LICA	ICGC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.1389
p.D140Y	DO50688	ORCA	ICGC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.7325
p.R142L	SIDM01078	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.8428
p.R142L	ACH-000790	Lung Cancer	CCLE	DYR	CBL_MET	140:142	Mutation altering degron motif	0.8428
p.R142L	SHP-77	lung	COSMIC	DYR	CBL_MET	140:142	Mutation altering degron motif	0.8428
p.V138A	SIDM01229	Neuroblastoma	GDSC	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778
p.V138A	ACH-000312	Neuroblastoma	CCLE	DYR	CBL_MET	140:142	Mutation rewiring degron network	0.2778

Kaplan plot for SMARCA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCA5

UniProt ID: O60264

Entrez ID: 8467

Protein name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCA5 in