DegronMD - O60381(HBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S159L	TCGA-4Z-AA84	BLCA	TCGA	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.S159L	TCGA-AP-A059	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.S159L	DO218988	BLCA	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.S159L	DO41361	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation blocking phosphorylation signal	0.75
p.R151H	TCGA-CQ-7068	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151H	DO233747	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151H	DO15551	HNSC	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151H	SIDM00980	Gastric Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151H	ACH-000948	Gastric Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.S158F	TCGA-HD-8634	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.S158F	TCGA-WE-A8K5	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.S158F	DO14196	HNSC	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.S158F	DO51282	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.S158F	SIDM00479	Esophageal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.S158F	ACH-000679	Esophageal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.S158F	OE19	oesophagus	COSMIC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation altering degron motif	0.9093
p.R151C	DO48326	ESCA	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151C	SIDM00373	Endometrial Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151C	SNG-M	endometrium	COSMIC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.R151S	DO231830	LINC	ICGC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.25
p.E162A	SIDM01107	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222
p.E162A	SK-MEL-1	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	154:158	Mutation rewiring degron network	0.2222

Kaplan plot for HBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HBP1

UniProt ID: O60381

Entrez ID: 26959

Protein name: HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HBP1 in