EIF4EBP3
UniProt ID: O60516
Entrez ID: 8637
Protein name: Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E...
FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. {ECO:0000250|UniProtKB:Q13541}.
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GO - Biological processes (BP):
negative regulation of translational initiation [GO:0045947]...
negative regulation of translational initiation [GO:0045947]
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GO - Molecular function (MF):
eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]...
eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]...
cytoplasm [GO:0005737]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]
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EIF4EBP3
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*NOTE: the Kaplan plots were collected from OncoLnc