NEMF
UniProt ID: O60524
Entrez ID: 9147
Protein name: Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees ribosomes from the stalled translation...
FUNCTION: As part of the ribosome quality control complex (RQC), a ribosome-associated complex, mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation. Thereby, frees ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell. It is responsible both for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and the recruitment of the E3 ubiquitin-protein ligase LTN1 to the ribosome quality control complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875). {ECO:0000269|PubMed:16103875, ECO:0000269|PubMed:25578875}.
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GO - Biological processes (BP):
CAT tailing [GO:0140708]; nuclear export [GO:0051168]; protein-containing complex assembly [GO:0065003]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]...
CAT tailing [GO:0140708]; nuclear export [GO:0051168]; protein-containing complex assembly [GO:0065003]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]
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GO - Molecular function (MF):
ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049]...
ribosomal large subunit binding [GO:0043023]; tRNA binding [GO:0000049]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleus [GO:0005634]; RQC complex [GO:1990112]...
cytosol [GO:0005829]; nucleus [GO:0005634]; RQC complex [GO:1990112]
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NEMF
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Kaplan plot for NEMF in
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*NOTE: the Kaplan plots were collected from OncoLnc