DegronMD - O60825(PFKFB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R461S	TCGA-A8-A07U	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1111
p.R480I	TCGA-AX-A05Z	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1389
p.R480I	TCGA-AX-A0J0	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1389
p.R478H	TCGA-CM-6171	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1944
p.E469K	DO51878	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7022
p.R463H	DO228542	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1667
p.L462F	DO13761	GBM	ICGC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1389
p.L462F	DO51275	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1389
p.R463P	DO223669	LGG	ICGC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1667
p.D466V	DO52332	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation blocking phosphorylation signal	0.6944
p.S466P	SIDM01951	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation blocking phosphorylation signal	0.6944
p.L469F	SIDM00611	Kidney Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.6981
p.L469F	KMRC-1	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.6981
p.R461C	SIDM00860	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1111
p.R461C	FADU	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1111
p.S472G	SIDM00151	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.8104
p.S472G	ACH-000966	Ovarian Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.8104
p.S472G	IGROV-1	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.8104
p.S473L	SIDM00534	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7667
p.S473L	HT-115	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation altering degron motif	0.7667
p.A464T	SIDM00150	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1944
p.A464T	KM12	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.1944
p.R459H	SIDM01753	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	469:473	Mutation rewiring degron network	0.0556

Kaplan plot for PFKFB2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PFKFB2

UniProt ID: O60825

Entrez ID: 5208

Protein name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PFKFB2 in