DegronMD - O60882(MMP20)

MMP20

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E467D	TCGA-86-6851	LUAD	TCGA	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.1111
p.E467D	DO23798	LUAD	ICGC	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.1111
p.S477Y	TCGA-A5-A2K5	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation altering degron motif	0.712
p.S477Y	DO41379	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation altering degron motif	0.712
p.D470G	TCGA-AA-3984	COAD	TCGA	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.1944
p.D470G	DO9002	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation rewiring degron network	0.1944
p.K468N	TCGA-D3-A2JC	SKCM	TCGA	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation substituting flanking lysine	0.25
p.K468N	DO47578	SKCM	ICGC	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation substituting flanking lysine	0.25
p.V475L	DO225012	BRCA	ICGC	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation altering degron motif	0.6765
p.T466K	DO229022	LICA	ICGC	VKSSS	DEG_SPOP_SBC_1	475:479	Mutation blocking phosphorylation signal	0.5278

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*NOTE: the Kaplan plots were collected from OncoLnc