DegronMD - O75069(TMCC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q215K	TCGA-91-6830	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.A231V	TCGA-AP-A1DK	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.A209T	TCGA-BR-A4PE	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.R219C	TCGA-D3-A8GI	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.719
p.S222F	TCGA-EE-A3JI	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7982
p.R217H	TCGA-L5-A8NM	ESCA	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.P218S	TCGA-XF-A9SZ	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6752
p.A210T	DO17482	KIRC	ICGC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.L214R	DO48766	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.I210V	SIDM00672	Hepatocellular Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.I210V	SIDM01112	Osteosarcoma	GDSC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.I210V	SIDM00621	Ewing's Sarcoma	GDSC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.A209V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.A209V	ACH-000937	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.A209V	PF-382	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.D232N	SIDM01321	Pancreatic Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0556
p.D232N	ACH-000307	Pancreatic Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0556
p.R217C	ACH-001395	Breast Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.A218S	NB14	autonomic ganglia	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7588
p.S214T	SNU-1040	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.R219Q	SNU-C2B	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6218
p.R219Q	SW948	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6218
p.V228I	KP-N-RT-BM-1	autonomic ganglia	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.S213C	DoTc2-4510	cervix	COSMIC	PRSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944

Kaplan plot for TMCC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMCC2

UniProt ID: O75069

Entrez ID: 9911

Protein name: Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMCC2 in