DegronMD - O75074(LRP3)

LRP3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I562V	TCGA-21-1080	LUSC	TCGA	PPSY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.I562V	DO26502	LUSC	ICGC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.Q559L	TCGA-66-2755	LUSC	TCGA	PPSY	ITCH	550:553	Mutation rewiring degron network	0.1667
p.Q559L	DO27365	LUSC	ICGC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.1667
p.R547Q	TCGA-A5-A0G2	UCEC	TCGA	PPSY	ITCH	550:553	Mutation rewiring degron network	0.25
p.R547Q	DO41235	UCEC	ICGC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.25
p.A558T	TCGA-A5-A1OF	UCEC	TCGA	PPSY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.A558T	DO42568	UCEC	ICGC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.1944
p.R546L	DO44858	LICA	ICGC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.2222
p.E543D	DO231839	LINC	ICGC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.1389
p.S552Y	SIDM01066	Melanoma	GDSC	PPSY	ITCH	550:553	Mutation altering degron motif	0.6009
p.S552Y	ACH-000650	Skin Cancer	CCLE	PPSY	ITCH	550:553	Mutation altering degron motif	0.6009
p.S552Y	IGR-37	skin	COSMIC	PPSY	ITCH	550:553	Mutation altering degron motif	0.6009
p.E541K	SIDM01608	Endometrial Carcinoma	GDSC	PPSY	ITCH	550:553	Mutation rewiring degron network	0.0833
p.E541K	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	550:553	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc