DegronMD - O75140(DEPDC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R834Q	TCGA-A5-A2K3	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056
p.R836H	TCGA-AX-A2H4	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.25
p.R829Q	TCGA-B5-A0JY	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.7329
p.R829Q	DO43041	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.7329
p.Y827H	TCGA-B7-A5TI	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2778
p.Y827H	DO222328	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2778
p.G1081R	TCGA-BH-A1F8	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.1667
p.G1081R	DO1512	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.1667
p.P820S	TCGA-D3-A51G	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.P820S	DO47700	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.M1074I	TCGA-EE-A3AD	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation altering degron motif	0.7618
p.M1074I	DO37707	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation altering degron motif	0.7618
p.S1061L	TCGA-HD-A6I0	HNSC	TCGA	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.0556
p.S1061L	DO49068	HNSC	ICGC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.0556
p.R836L	TCGA-LN-A49K	ESCA	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.25
p.R836C	TCGA-YZ-A985	UVM	TCGA	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.25
p.S837R	DO48442	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.T1072A	DO234462	ESAD	ICGC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation altering degron motif	0.7139
p.R843L	DO228952	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0556
p.A1062S	DO229006	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.0833
p.R843Q	DO43899	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0556
p.P820L	ACH-001333	Cervical Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.P820L	C-33-A	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.Q842H	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.I821S	HCC1419	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation substituting flanking lysine	0.2222
p.T836M	SNU-1040	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.25
p.S1069R	NCI-SNU-1	stomach	COSMIC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.2778
p.P829L	C-33-A	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.7582
p.P837L	C-33-A	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.Q1077P	BC-1	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.2778
p.Q823H	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1667
p.Q1069P	BC-1	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	1071:1075	Mutation rewiring degron network	0.2778
p.D829Y	HCC2998	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.7325
p.Q824R	RKO	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1944

Kaplan plot for DEPDC5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DEPDC5

UniProt ID: O75140

Entrez ID: 9681

Protein name: GATOR complex protein DEPDC5 (DEP domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DEPDC5 in