DegronMD - O75326(SEMA7A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P74Q	TCGA-AP-A05H	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1111
p.P74Q	DO43546	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1111
p.D85N	DO218976	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.6932
p.L78R	DO230326	COCA	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.F78Y	DO219918	DLBC	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.R80Q	DO233259	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.D73E	DO229031	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.D73E	NB12	autonomic ganglia	COSMIC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.D72N	DO44879	LIHC	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.D72N	SF539	central nervous system	COSMIC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.D72N	MES-SA	soft tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.D72N	CW-2	large intestine	COSMIC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.L92V	DO40859	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.T76M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.T76M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.T76M	ACH-000995	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.T76M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.F79L	MFE-319	endometrium	COSMIC	PGSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25

Kaplan plot for SEMA7A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA7A

UniProt ID: O75326

Entrez ID: 8482

Protein name: Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA7A in