DegronMD - O75334(PPFIA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S565I	TCGA-25-2042	OV	TCGA	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.25
p.S567F	TCGA-50-5931	LUAD	TCGA	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.3056
p.I575M	TCGA-DI-A1BU	UCEC	TCGA	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1944
p.R570K	TCGA-EE-A2GC	SKCM	TCGA	DYR	CBL_MET	568:570	Mutation altering degron motif	0.7237
p.R578H	DO225301	BRCA	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1111
p.R578H	DO38487	STAD	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1111
p.L577F	DO51227	BRCA	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1389
p.E564K	DO222735	BTCA	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.2222
p.R578C	DO222834	BTCA	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1111
p.R578C	DO51645	CESC	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1111
p.R578C	DO26444	LUSC	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1111
p.E580D	DO234270	ESAD	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.0556
p.E580D	DO234298	ESAD	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.0556
p.Q569R	DO51574	KIRP	ICGC	DYR	CBL_MET	568:570	Mutation altering degron motif	0.7329
p.N562K	DO229045	LICA	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1667
p.E576K	DO37667	SKCM	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1667
p.E576K	DO47919	STAD	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1667
p.L558F	DO37770	SKCM	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.0556
p.E571K	DO50299	SKCM	ICGC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.3056
p.Y569H	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	568:570	Mutation altering degron motif	0.7229
p.D564N	SIDM01059	Melanoma	GDSC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.2222
p.D564N	ACH-000915	Skin Cancer	CCLE	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.2222
p.D564N	IPC-298	skin	COSMIC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.2222
p.P566S	SW684	soft tissue	COSMIC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.2778
p.T575N	NCI-H716	large intestine	COSMIC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.1944
p.P565S	COLO-792	skin	COSMIC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.25
p.P565L	COLO-792	skin	COSMIC	DYR	CBL_MET	568:570	Mutation rewiring degron network	0.25
p.R568Q	SNU-81	large intestine	COSMIC	DYR	CBL_MET	568:570	Mutation altering degron motif	0.7329
p.L568F	NCI-H1623	lung	COSMIC	DYR	CBL_MET	568:570	Mutation altering degron motif	0.6981
p.Y573H	LNCaP-Clone-FGC	prostate	COSMIC	DYR	CBL_MET	568:570	Mutation substituting flanking lysine	0.3611

Kaplan plot for PPFIA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPFIA2

UniProt ID: O75334

Entrez ID: 8499

Protein name: Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPFIA2 in