DegronMD - O75508(CLDN11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S197I	TCGA-96-7544	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.8453
p.S197I	DO228952	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.8453
p.S197I	DO26425	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.8453
p.R189C	TCGA-BG-A0MU	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1944
p.R189C	DO43915	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1944
p.V207I	TCGA-EA-A410	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	DO49929	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	DO232761	PBCA	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	SIDM01169	Ovarian Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	SIDM00889	Cervical Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	ACH-000885	Ovarian Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	ACH-001333	Cervical Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	TOV-21G	ovary	COSMIC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.V207I	C-33-A	cervix	COSMIC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0833
p.S198F	TCGA-EE-A2A2	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.9093
p.S198F	DO37583	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.9093
p.P199S	TCGA-ER-A19F	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.P199S	DO37679	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.S198A	TCGA-WE-AAA0	SKCM	TCGA	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.87
p.S198A	DO51294	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.87
p.A202T	DO228940	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.R189S	DO44792	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1944
p.A202V	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.A202V	ACH-002157	Lung Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.A202V	LC-2-ad	lung	COSMIC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.A184T	SIDM01617	Endometrial Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0556
p.A184T	ACH-000994	Endometrial/Uterine Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.0556

Kaplan plot for CLDN11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLDN11

UniProt ID: O75508

Entrez ID: 5010

Protein name: Claudin-11 (Oligodendrocyte-specific protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLDN11 in