DegronMD - O75569(PRKRA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A29T	TCGA-78-7160	LUAD	TCGA	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1389
p.P31S	TCGA-A6-6780	COAD	TCGA	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.0833
p.T9K	DO52549	BRCA	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1111
p.E28K	DO9034	COAD	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1667
p.V13A	DO233777	GACA	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.2222
p.R7S	DO229019	LICA	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.0556
p.H15Q	DO23332	LINC	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.2778
p.P11L	DO230527	LUSC	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1667
p.P11L	SIDM00969	Ovarian Carcinoma	GDSC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1667
p.R31T	DO46917	RECA	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.0833
p.F21L	DO229275	THCA	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation altering degron motif	0.587
p.A8P	DO229250	THCA	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation blocking phosphorylation signal	0.5278
p.G8V	DO41644	UCEC	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation blocking phosphorylation signal	0.5278
p.T21A	DO43755	UCEC	ICGC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation altering degron motif	0.7139
p.M26K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.2222
p.M26K	ACH-000562	Lung Cancer	CCLE	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.2222
p.M26K	HCC-78	lung	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.2222
p.I27T	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1944
p.I27T	SIDM00564	Ovarian Carcinoma	GDSC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1944
p.I27T	ACH-000527	Ovarian Cancer	CCLE	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1944
p.I27T	ACH-000561	Esophageal Cancer	CCLE	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1944
p.I27T	OVISE	ovary	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1944
p.I27T	T-T	oesophagus	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.1944
p.K25T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation substituting flanking lysine	0.3611
p.I16T	OVISE	ovary	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.3056
p.I16T	T-T	oesophagus	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.3056
p.M15K	HCC-78	lung	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.2778
p.S32T	LNCaP-Clone-FGC	prostate	COSMIC	DSGTFS	DEG_SCF_TRCP1_1	17:22	Mutation rewiring degron network	0.0556

Kaplan plot for PRKRA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRKRA

UniProt ID: O75569

Entrez ID: 8575

Protein name: Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRKRA in