DegronMD - O75626(PRDM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P328T	TCGA-EE-A29S	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.P328T	DO37936	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.R326C	TCGA-MQ-A4LP	MESO	TCGA	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2222
p.R326C	SIDM01322	Oral Cavity Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2222
p.S327C	TCGA-Z6-AAPN	ESCA	TCGA	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.S342I	DO229015	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation blocking phosphorylation signal	0.5556
p.R340K	DO23218	LINC	ICGC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1667
p.D344N	SIDM00155	Head and Neck Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.D344N	PCI-38	upper aerodigestive tract	COSMIC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0556
p.R326H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2222
p.R326H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2222
p.A343V	ACH-000953	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0833
p.A343V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.0833
p.T323M	ACH-000965	Endometrial/Uterine Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.T323M	RL95-2	endometrium	COSMIC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.P337S	HGC-27	stomach	COSMIC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.L322V	LK-2	lung	COSMIC	PSSTT	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1111

Kaplan plot for PRDM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM1

UniProt ID: O75626

Entrez ID: 639

Protein name: PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM1 in