DegronMD - O94988(FAM13A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S434Y	TCGA-AP-A1DV	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2778
p.S434Y	TCGA-DF-A2KU	UCEC	TCGA	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2778
p.R425W	DO13863	GBM	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.25
p.Q429H	DO14470	HNSC	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.7582
p.A434D	DO229015	LICA	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2778
p.K418R	DO222644	MELA	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0556
p.V427G	DO229191	THCA	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V427G	DO229192	THCA	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.V427G	DO229084	THCA	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.S442F	DO41235	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0556
p.L431I	DO42673	UCEC	ICGC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.7174
p.P433S	SIDM01106	Melanoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.P433S	ACH-000822	Skin Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.P433S	SK-MEL-24	skin	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.I427V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056
p.R422S	SIDM00068	Colorectal Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.R422S	SIDM01318	Hepatocellular Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.R422S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.R422S	ACH-000845	Lung Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.R422S	ACH-001318	Liver Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.R422S	ACH-002394	Colon/Colorectal Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.R422S	GEO	large intestine	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.K424T	SIDM00863	Burkitt's Lymphoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation substituting flanking lysine	0.3333
p.K424T	EB2	haematopoietic and lymphoid tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation substituting flanking lysine	0.3333
p.F436L	SIDM00150	Colorectal Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.F436L	ACH-000969	Colon/Colorectal Cancer	CCLE	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.F436L	KM12	large intestine	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.2222
p.N437S	SIDM01781	Gastric Carcinoma	GDSC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1944
p.N428S	ACH-000167	Myeloma	CCLE	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation altering degron motif	0.5958
p.D422Y	HN	upper aerodigestive tract	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.1667
p.Q441K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.0833
p.Q427K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NKENT	DEG_APCC_KENBOX_2	428:432	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM13A

UniProt ID: O94988

Entrez ID: 10144

Protein name: Protein FAM13A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM13A in