DegronMD - O95409(ZIC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S454F	TCGA-06-5416	GBM	TCGA	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S454F	DO10880	GBM	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S454T	TCGA-77-8133	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S454T	DO27039	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S444R	TCGA-AP-A1DK	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S444R	DO42033	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.S444R	ACH-000773	Lymphoma	CCLE	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25
p.Q448R	TCGA-UZ-A9PM	KIRP	TCGA	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.6218
p.Q448R	DO219702	KIRP	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.6218
p.P447T	DO36881	READ	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.7031
p.L453P	DO229259	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.2778
p.S450R	DO229264	THCA	ICGC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.7427
p.S451A	SIDM02064	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.7588

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons