DegronMD - O95415(BRI3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y23H	DO52699	CLLE	ICGC	PPAY	ITCH	11:14	Mutation blocking phosphorylation signal	0.5278
p.Y44C	DO227906	COCA	ICGC	PPPY	ITCH	39:42	Mutation rewiring degron network	0.2778
p.P12A	DO228969	LICA	ICGC	PPAY	ITCH	11:14	Mutation altering degron motif	0.7503
p.A35S	DO229015	LICA	ICGC	PPPY	ITCH	39:42	Mutation rewiring degron network	0.2222
p.G21C	DO25189	LUAD	ICGC	PPAY	ITCH	11:14	Mutation rewiring degron network	0.1389
p.P34S	DO220867	MELA	ICGC	PPPY	ITCH	39:42	Mutation rewiring degron network	0.1944
p.P38L	ACH-000747	Lung Cancer	CCLE	PPPY	ITCH	39:42	Mutation rewiring degron network	0.3056
p.A36S	ACH-000807	Brain Cancer	CCLE	PPPY	ITCH	39:42	Mutation rewiring degron network	0.25

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons