DegronMD - O95568(METTL18)

METTL18

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S84R	TCGA-CG-4466	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.8538
p.S84R	DO38695	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.8538
p.P78L	TCGA-EE-A2GT	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.P78L	DO37946	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.K93Q	DO10172	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation substituting flanking lysine	0.2222
p.E89Q	SIDM00425	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.E89Q	OVTOKO	ovary	COSMIC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.H91R	SIDM01005	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.H91R	ACH-000263	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.H91R	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.S80G	SIDM01608	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056
p.S80G	ACH-000990	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc