DegronMD - O95977(S1PR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S368T	TCGA-18-4721	LUSC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.S368T	DO27104	LUSC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.S364C	TCGA-55-8205	LUAD	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1389
p.S364C	DO48884	LUAD	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1389
p.E373Q	TCGA-85-A4CL	LUSC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.5633
p.E373Q	DO45454	LUSC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.5633
p.R382W	TCGA-A6-5665	COAD	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.R382W	DO9756	COAD	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.R372W	TCGA-AX-A2HC	UCEC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.8634
p.R372W	DO41572	UCEC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.8634
p.R372W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.8634
p.R372W	ACH-000995	Leukemia	CCLE	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.8634
p.R372W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.8634
p.S376P	TCGA-B0-5691	KIRC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.5641
p.S376P	DO20496	KIRC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.5641
p.R362C	TCGA-BP-4164	KIRC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362C	TCGA-ZF-A9RL	BLCA	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362C	DO48378	BLCA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362C	DO219078	BLCA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362C	DO19258	KIRC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362H	TCGA-CD-A4MG	STAD	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362H	DO48009	STAD	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362H	SIDM00217	Colorectal Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362H	ACH-000999	Colon/Colorectal Cancer	CCLE	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.R362H	SNU-1040	large intestine	COSMIC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.0833
p.S377R	TCGA-CJ-4907	KIRC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.7427
p.S377R	DO19743	KIRC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.7427
p.R382Q	TCGA-CV-6962	HNSC	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.R382Q	DO14307	HNSC	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.R382Q	SIDM00217	Colorectal Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.R382Q	ACH-000999	Colon/Colorectal Cancer	CCLE	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.R382Q	SNU-1040	large intestine	COSMIC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.25
p.S364F	TCGA-KQ-A41S	BLCA	TCGA	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1389
p.S364F	DO223593	BLCA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1389
p.S377N	DO228935	COCA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.7069
p.G363D	DO233935	GACA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1111
p.V381L	DO228952	LICA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.2778
p.R370Q	DO222880	MELA	ICGC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.3056
p.R370Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.3056
p.R370Q	ACH-000925	Lung Cancer	CCLE	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.3056
p.R365L	SIDM01139	Pancreatic Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00582	Pancreatic Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00338	Acute Myeloid Leukemia	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00614	Hepatocellular Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00565	Oral Cavity Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00602	Gastric Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00007	Other Solid Cancers	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00573	Glioblastoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00992	Thyroid Gland Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01161	Other Sarcomas	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00290	Gastric Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00112	Kidney Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00252	Biliary Tract Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00276	Biliary Tract Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00140	Melanoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00469	Pancreatic Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00566	Oral Cavity Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00560	Gastric Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00699	Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM00980	Gastric Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01695	Acute Myeloid Leukemia	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01582	Gastric Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01394	Kidney Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01561	Melanoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01694	B-Lymphoblastic Leukemia	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.R365L	SIDM01391	Neuroblastoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.1667
p.V381M	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.2778
p.V381M	SIDM00506	Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation rewiring degron network	0.2778
p.R372Q	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.7329
p.R372Q	ACH-000603	Lung Cancer	CCLE	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.7329
p.R372Q	BEN	lung	COSMIC	MREPLSSIS	DEG_APCC_DBOX_1	371:379	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

S1PR4

UniProt ID: O95977

Entrez ID: 8698

Protein name: Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for S1PR4 in