DegronMD - O96013(PAK4)

PAK4

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R254Q	TCGA-EK-A2PM	CESC	TCGA	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.R254Q	DO49941	CESC	ICGC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.Q241H	TCGA-HW-8320	LGG	TCGA	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.647
p.Q241H	DO48713	LGG	ICGC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.647
p.S246F	TCGA-Q1-A73O	CESC	TCGA	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2778
p.S246F	DO51612	CESC	ICGC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2778
p.P250L	DO220902	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1667
p.P250L	DO222423	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1667
p.P250L	DO37425	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1667
p.R252Q	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1111
p.R252Q	ACH-001738	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1111
p.R252Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.1111
p.A248V	NCI-H630	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.G254V	NCI-H838	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.D236Y	FU-OV-1	ovary	COSMIC	PQSSS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc