DegronMD - P00736(C1R)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L537F	TCGA-05-5715	LUAD	TCGA	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1111
p.L537F	DO225343	BRCA	ICGC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1111
p.L537F	DO25464	LUAD	ICGC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1111
p.G545E	TCGA-DA-A1IC	SKCM	TCGA	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7199
p.G545E	DO37430	SKCM	ICGC	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7199
p.L535M	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.0556
p.L535M	DO22237	LGG	ICGC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.0556
p.E548K	TCGA-EB-A41A	SKCM	TCGA	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.3056
p.E548K	DO37429	SKCM	ICGC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.3056
p.G545R	TCGA-KN-8428	KICH	TCGA	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7568
p.G545R	DO220484	KICH	ICGC	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7568
p.G545R	ACH-000984	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7568
p.D554N	TCGA-WE-AAA3	SKCM	TCGA	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1389
p.D554N	DO51295	SKCM	ICGC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1389
p.G543A	DO50337	ESAD	ICGC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.2778
p.G547E	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7199
p.G547E	T-T	oesophagus	COSMIC	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7199
p.R553S	SIDM00617	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R553S	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R553S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R553S	LU-99A	lung	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R553S	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R553S	JHH-2	liver	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.M544V	SIDM00220	Ovarian Carcinoma	GDSC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.3056
p.M544V	OC-314	ovary	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.3056
p.M547T	ACH-000974	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7423
p.M547T	ACH-002026	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	545:547	Mutation altering degron motif	0.7423
p.R539S	LU-99A	lung	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R539S	JHH-2	liver	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.R539S	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.1667
p.D548N	COLO-678	large intestine	COSMIC	DYR	CBL_MET	545:547	Mutation rewiring degron network	0.3056

Kaplan plot for C1R in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1R

UniProt ID: P00736

Entrez ID: 715

Protein name: Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1R in