DegronMD - P01344(IGF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R129H	TCGA-AJ-A3EL	UCEC	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8244
p.P143H	TCGA-BQ-7059	KIRP	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.0833
p.R120C	TCGA-CK-4951	COAD	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation substituting flanking lysine	0.2778
p.R120C	TCGA-FJ-A3ZF	BLCA	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation substituting flanking lysine	0.2778
p.R120H	TCGA-D7-A4Z0	STAD	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation substituting flanking lysine	0.2778
p.E124D	TCGA-DZ-6133	KIRP	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2778
p.R129C	TCGA-F7-A624	HNSC	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8301
p.V123I	TCGA-HU-A4G2	STAD	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.25
p.R117H	TCGA-XU-A936	THYM	TCGA	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.0833
p.L136V	DO219006	BLCA	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2778
p.R130H	DO52081	HNSC	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8244
p.R130C	DO22237	LGG	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.8301
p.R130S	DO229015	LICA	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7427
p.R130S	DO218921	LUAD	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7427
p.F116Y	DO50749	LICA	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation blocking phosphorylation signal	0.5
p.R128L	DO23597	LUAD	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7316
p.L136I	DO37507	SKCM	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2778
p.F117L	DO223906	SKCM	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.0833
p.G132S	DO43891	UCEC	ICGC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.6993
p.T138M	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2222
p.T138M	SIDM00701	Non-Cancerous	GDSC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2222
p.G139V	ACH-000724	Bladder Cancer	CCLE	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.G139V	HT-1376	urinary tract	COSMIC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1944
p.G142V	HT-1376	urinary tract	COSMIC	LRRGLPALL	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1111

Kaplan plot for IGF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGF2

UniProt ID: P01344

Entrez ID: 3481

Protein name: Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGF2 in