DegronMD - P02814(SMR3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R58K	TCGA-D9-A3Z1	SKCM	TCGA	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.R58K	DO222653	MELA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.R58K	DO38105	SKCM	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.R58K	SIDM00909	Melanoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.R58K	ACH-000644	Skin Cancer	CCLE	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.R58K	COLO-829	skin	COSMIC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P50S	TCGA-EE-A183	SKCM	TCGA	PPPY	ITCH	51:54	Mutation rewiring degron network	0.3056
p.P50S	DO37715	SKCM	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.3056
p.P52S	TCGA-FS-A1Z3	SKCM	TCGA	PPPY	ITCH	51:54	Mutation altering degron motif	0.6752
p.P52S	DO37635	SKCM	ICGC	PPPY	ITCH	51:54	Mutation altering degron motif	0.6752
p.R58T	TCGA-G2-A2EJ	BLCA	TCGA	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.R58T	DO554	BLCA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P52L	TCGA-L9-A444	LUAD	TCGA	PPPY	ITCH	51:54	Mutation altering degron motif	0.7582
p.P52L	DO26015	LUAD	ICGC	PPPY	ITCH	51:54	Mutation altering degron motif	0.7582
p.P62T	DO225151	BRCA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1111
p.G55D	DO234345	ESAD	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.3056
p.G57E	DO220877	MELA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.25
p.G57E	DO220880	MELA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.25
p.G57E	DO222868	MELA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.25
p.G57E	DO222908	MELA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.25
p.G44E	DO220890	MELA	ICGC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.1389
p.P47L	SIDM00480	Ovarian Carcinoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM00441	Acute Myeloid Leukemia	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM00474	Ovarian Carcinoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM00817	Kidney Carcinoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM00085	Glioma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM00861	Ovarian Carcinoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P47L	SIDM01580	Melanoma	GDSC	PPPY	ITCH	51:54	Mutation rewiring degron network	0.2222
p.P64L	ACH-001688	Kidney Cancer	CCLE	PPPY	ITCH	51:54	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMR3B

UniProt ID: P02814

Entrez ID: 10879

Protein name: Submaxillary gland androgen-regulated protein 3B (Proline-rich peptide P-B) (Proline-rich protein 3) [Cleaved into: Peptide P-A; Peptide D1A]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMR3B in