DegronMD - P04275(VWF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S209T	TCGA-B8-5164	KIRC	TCGA	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.6005
p.S209T	DO17018	KIRC	ICGC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.6005
p.W199C	TCGA-CK-4951	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1667
p.P205L	TCGA-EB-A431	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.7582
p.A203E	DO229031	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.2778
p.G215E	DO220903	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1667
p.G215E	DO37404	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1667
p.T218I	DO37671	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.C200R	SIDM00831	Head and Neck Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.C200R	ACH-000207	Head and Neck Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.C200R	Detroit562	upper aerodigestive tract	COSMIC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.K219N	SIDM01196	Hepatocellular Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation substituting flanking lysine	0.1667
p.K219N	SNU-475	liver	COSMIC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation substituting flanking lysine	0.1667
p.S214F	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.S214F	ACH-000628	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.S214F	NCI-H596	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.R202W	ACH-001518	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25

Kaplan plot for VWF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWF

UniProt ID: P04275

Entrez ID: 7450

Protein name: von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWF in