DegronMD - P05787(KRT8)

KRT8

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S438G	TCGA-A6-5657	COAD	TCGA	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.5278
p.T441M	TCGA-DU-6392	LGG	TCGA	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.6111
p.T441M	DO22237	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.6111
p.M437L	TCGA-LN-A4A2	ESCA	TCGA	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation blocking phosphorylation signal	0.5
p.A447T	DO43755	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.7139
p.A447T	ACH-002293	Lymphoma	CCLE	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.7139
p.G449A	SIDM00659	Glioblastoma	GDSC	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.754
p.G449A	M059J	central nervous system	COSMIC	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.754
p.S451F	ACH-000812	Skin Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation altering degron motif	0.9093
p.G440D	ACH-000966	Ovarian Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.1389
p.T444A	SNU-407	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	447:451	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc