DegronMD - P06727(APOA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A271D	TCGA-44-8120	LUAD	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6682
p.A271D	DO45402	LUAD	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.6682
p.A258T	TCGA-AX-A2HC	UCEC	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.A258T	DO41572	UCEC	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.L278P	TCGA-AZ-6601	COAD	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.L278P	DO8119	COAD	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1389
p.A258G	TCGA-ZP-A9CZ	LIHC	TCGA	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.A258G	DO52330	LIHC	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.1944
p.R264L	DO225081	BRCA	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8428
p.R264L	DO52559	BRCA	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8428
p.E272K	DO229177	LMS	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.3056
p.R275C	DO33091	PACA	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.2222
p.A254T	DO232899	PEME	ICGC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.0833
p.K253N	SIDM00583	Pancreatic Carcinoma	GDSC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation substituting flanking lysine	0.1667
p.K253N	ACH-001107	Pancreatic Cancer	CCLE	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation substituting flanking lysine	0.1667
p.K253N	KP-1N	pancreas	COSMIC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation substituting flanking lysine	0.1667
p.R264W	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8634
p.R264W	CRO-AP3	NS	COSMIC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation altering degron motif	0.8634
p.G280V	SIDM00685	Glioblastoma	GDSC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.0833
p.G280V	ACH-000819	Brain Cancer	CCLE	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.0833
p.G280V	LN-18	central nervous system	COSMIC	LRQRLAPLA	DEG_APCC_DBOX_1	263:271	Mutation rewiring degron network	0.0833

Kaplan plot for APOA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

APOA4

UniProt ID: P06727

Entrez ID: 337

Protein name: Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for APOA4 in