DegronMD - P07196(NEFL)

FUNCTION: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08551}.

GO - Biological processes (BP): anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; intermediate filament organization [GO:0045109]; intermediate filament polymerization or depolymerization [GO:0045105]; locomotio... View more >>

GO - Molecular function (MF): identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein-containing complex binding [GO:0044877]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; protein-macromolecule adaptor activity [GO:0030674]; structural constituent of cytoskele... View more >>

GO - Cellular component (CC): axon [GO:0030424]; axon cytoplasm [GO:1904115]; cholinergic synapse [GO:0098981]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; neurofilament [GO:0005883]; neuromuscular junction [GO:0031594]; postsynaptic intermediate filament cytoskeleton [GO:0099160]; presynaptic interme... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S48Y	SIDM01475	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	46:50	Mutation altering degron motif	0.712
p.R55H	SIDM01314	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.R55C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.R55C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.1944
p.R37H	SIDM00216	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	46:50	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEFL

UniProt ID: P07196

Entrez ID: 4747

Protein name: Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for NEFL in