DegronMD - P08670(VIM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F15L	TCGA-21-5782	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.F15L	DO27120	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.R36S	TCGA-D3-A2JH	SKCM	TCGA	VTTST	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.3056
p.R36S	DO47263	SKCM	ICGC	VTTST	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.3056
p.S22I	TCGA-DD-AACY	LIHC	TCGA	VTTST	DEG_SPOP_SBC_1	31:35	Mutation blocking phosphorylation signal	0.5278
p.S22I	DO219567	LIHC	ICGC	VTTST	DEG_SPOP_SBC_1	31:35	Mutation blocking phosphorylation signal	0.5278
p.F15V	TCGA-FI-A2D5	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.F15V	DO41331	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.S8L	TCGA-XF-A9SJ	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.8778
p.S8L	DO219045	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.8778
p.T33M	TCGA-XK-AAIW	PRAD	TCGA	VTTST	DEG_SPOP_SBC_1	31:35	Mutation altering degron motif	0.8534
p.T33M	DO51407	PRAD	ICGC	VTTST	DEG_SPOP_SBC_1	31:35	Mutation altering degron motif	0.8534
p.R45H	DO234360	ESAD	ICGC	VTTST	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.0556
p.P24L	DO233088	GACA	ICGC	VTTST	DEG_SPOP_SBC_1	31:35	Mutation rewiring degron network	0.1389
p.P18T	DO50712	ORCA	ICGC	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1111
p.V31A	DO232224	PBCA	ICGC	VTTST	DEG_SPOP_SBC_1	31:35	Mutation altering degron motif	0.5825
p.S8P	SIDM01608	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7863
p.S8P	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	6:10	Mutation altering degron motif	0.7863
p.Y38H	ACH-001735	Leukemia	CCLE	VTTST	DEG_SPOP_SBC_1	31:35	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for VIM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VIM

UniProt ID: P08670

Entrez ID: 7431

Protein name: Vimentin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VIM in