DegronMD - P09848(LCT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1227V	TCGA-37-A5EL	LUSC	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056
p.E1227V	DO223718	LUSC	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056
p.D1229N	TCGA-55-8208	LUAD	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.25
p.D1229N	TCGA-D3-A51G	SKCM	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.25
p.D1229N	DO51192	LUAD	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.25
p.D1229N	DO47700	SKCM	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.25
p.E1231Q	TCGA-92-8064	LUSC	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1944
p.E1231Q	DO26957	LUSC	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1944
p.E1231D	TCGA-AX-A2HC	UCEC	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1944
p.E1231D	DO41572	UCEC	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1944
p.Q1230H	TCGA-AZ-4315	COAD	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.2222
p.Q1230H	DO8842	COAD	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.2222
p.E1227K	TCGA-B5-A11E	UCEC	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056
p.E1227K	DO41644	UCEC	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056
p.P1219H	TCGA-B5-A5OC	UCEC	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.2222
p.P1219H	DO52405	UCEC	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.2222
p.D1228Y	TCGA-MP-A4TF	LUAD	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.2778
p.D1228Y	DO45316	LUAD	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.2778
p.N1222S	TCGA-P5-A72Z	LGG	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056
p.N1222S	DO219828	LGG	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056
p.E1234K	TCGA-RS-A6TP	HNSC	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1111
p.E1234K	DO219062	HNSC	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1111
p.E1235K	TCGA-YD-A89C	SKCM	TCGA	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.0833
p.E1235K	DO219501	SKCM	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.0833
p.V1214M	DO222569	BTCA	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.0833
p.Q1215R	DO233262	GACA	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1111
p.M1232I	DO50969	LICA	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.1667
p.N1222K	DO51486	PACA	ICGC	PPSY	ITCH	1223:1226	Mutation rewiring degron network	0.3056

Kaplan plot for LCT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LCT

UniProt ID: P09848

Entrez ID: 3938

Protein name: Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LCT in