DegronMD - P09871(C1S)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D556E	TCGA-58-8391	LUSC	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.D556E	DO45440	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.M560I	TCGA-D3-A1Q6	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1944
p.M560I	DO37450	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1944
p.D556N	TCGA-EO-A22U	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.D556N	DO43755	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.C549Y	TCGA-FI-A2D0	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2778
p.C549Y	DO43891	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2778
p.C549Y	SIDM00282	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2778
p.C549Y	CW-2	large intestine	COSMIC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2778
p.P551Q	TCGA-G2-AA3B	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7035
p.P551Q	DO51882	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7035
p.L564M	TCGA-IB-7651	PAAD	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.0833
p.L564M	DO46657	PAAD	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.0833
p.V545I	TCGA-VP-AA1N	PRAD	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1667
p.V545I	TCGA-VQ-A8P2	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1667
p.V545I	DO222503	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1667
p.V545I	DO51393	PRAD	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1667
p.V545I	DO51761	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1667
p.G542R	DO222542	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.0833
p.S555F	DO222847	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7982
p.C543Y	CW-2	large intestine	COSMIC	PGTSS	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1111

Kaplan plot for C1S in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1S

UniProt ID: P09871

Entrez ID: 716

Protein name: Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1S in