DegronMD - P0C1Z6(TFPT)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E141D	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.0833
p.R132W	TCGA-CD-A4MG	STAD	TCGA	DYR	CBL_MET	130:132	Mutation altering degron motif	0.8634
p.R132W	SIDM01960	Colorectal Carcinoma	GDSC	DYR	CBL_MET	130:132	Mutation altering degron motif	0.8634
p.S126Y	DO221539	PACA	ICGC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.2222
p.R123W	DO48009	STAD	ICGC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.1389
p.E132D	DO41361	UCEC	ICGC	DYR	CBL_MET	130:132	Mutation altering degron motif	0.6758
p.I138T	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.1667
p.I138T	MN-60	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.1667
p.M121T	SIDM00537	Colorectal Carcinoma	GDSC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.0833
p.M121T	ACH-000982	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.0833
p.M121T	ACH-001345	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.0833
p.M121T	GP5d	large intestine	COSMIC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.0833
p.G128R	SIDM01470	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.2778
p.G128R	ACH-000387	Leukemia	CCLE	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.2778
p.I129T	MN-60	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	130:132	Mutation rewiring degron network	0.3056

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons