DegronMD - P0C7U3(ZDHHC11B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A357V	DO233882	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1389
p.P358S	DO48761	LIRI	ICGC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1111
p.P336L	DO220891	MELA	ICGC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0556
p.P358R	DO46420	OV	ICGC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1111
p.P347L	SIDM00969	Ovarian Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6471
p.P347L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6471
p.P347L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6471
p.S338P	SIDM00193	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1111
p.S338P	SNU-81	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1111
p.Q341R	SIDM00660	Colorectal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.Q341R	LS-411N	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.T349I	SIDM00445	Esophageal Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7078
p.T349I	SIDM01746	Osteosarcoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7078
p.T349I	OACp4C	oesophagus	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7078
p.Q341E	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.S349P	SNU-81	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6752
p.K339T	NCI-H23	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation substituting flanking lysine	0.25
p.K350T	NCI-H23	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7306
p.T360I	OACp4C	oesophagus	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0556
p.Q352R	LS-411N	large intestine	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2778
p.C337Y	HCC-15	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0833

Kaplan plot for ZDHHC11B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZDHHC11B

UniProt ID: P0C7U3

Entrez ID:

Protein name: Probable palmitoyltransferase ZDHHC11B (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11B) (DHHC-11B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZDHHC11B in