DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
FAM90A14
UniProt ID:
P0C7W9
Entrez ID:
Protein name:
Putative protein FAM90A14
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
FAM90A14
D
D
M
M
A
R
R
D
P
T
S
W
A
K
R
L
V
R
A
Q
T
L
Q
K
Q
R
R
A
P
V
G
P
R
A
P
P
P
D
E
E
D
P
R
L
K
C
K
N
C
G
A
F
G
H
T
A
R
S
T
R
C
P
M
K
C
W
K
A
A
L
V
P
A
T
L
G
K
K
E
G
K
E
N
L
K
P
W
K
P
R
V
E
A
N
P
G
P
L
N
K
D
K
G
E
K
E
E
R
P
R
Q
Q
D
P
Q
R
K
A
L
L
H
M
F
S
G
K
P
P
E
K
P
L
P
N
G
K
G
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E
P
S
D
Y
L
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V
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M
P
V
H
T
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A
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S
S
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G
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M
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P
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G
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R
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Q
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C
P
P
A
A
T
H
S
L
G
L
G
S
N
L
S
F
G
P
G
A
K
R
P
A
Q
A
P
I
Q
A
C
L
N
F
P
K
K
P
R
L
G
P
F
Q
I
P
E
S
A
I
Q
G
G
E
L
G
A
P
E
N
L
Q
P
P
P
A
A
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E
L
G
P
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M
G
R
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S
V
D
R
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C
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N
G
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W
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L
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A
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F
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G
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A
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R
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D
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50
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Residue number
0
Number of mutated samples
0
0.5
1
1.5
2
2.5
3
Phosphorylation sites
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Cancer
Sample
Mutation type
Dataset
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entries
Search:
Degron hit
Class
E3 ligase
Source protein
Location
Detail
KRPRLDPVL
DEG_APCC_DBOX_1
APC,CDC20,FZR1
Putative protein FAM90A14
157:165
More..
GREPLLVVK
DEG_APCC_DBOX_1
APC,CDC20,FZR1
Putative protein FAM90A14
219:227
More..
GKENL
DEG_APCC_KENBOX_2
APC,CDC20,FZR1
Putative protein FAM90A14
78:82
More..
VHTTS
DEG_SPOP_SBC_1
SPOP
Putative protein FAM90A14
152:156
More..
VSSSS
DEG_SPOP_SBC_1
SPOP
Putative protein FAM90A14
452:456
More..
Showing 1 to 5 of 5 entries
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Mutation
Sample
Cancer
Degron hit
Class
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Dataset
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Mutation
Sample
Cancer
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Degron hit
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Type
Impact score
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Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for FAM90A14 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc