FDX1
UniProt ID: P10109
Entrez ID: 2230
Protein name: Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 th...
FUNCTION: Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). {ECO:0000250|UniProtKB:P00257, ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.
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GO - Biological processes (BP):
cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol metabolic process [GO:0008203]; electron transport chain [GO:0022900]; hormone biosynthetic process [GO:0042446]; P450-containing electron transport chain [GO:0140647]; positive regulation of oxidoreduct...
cellular response to cAMP [GO:0071320]; cellular response to forskolin [GO:1904322]; cholesterol metabolic process [GO:0008203]; electron transport chain [GO:0022900]; hormone biosynthetic process [GO:0042446]; P450-containing electron transport chain [GO:0140647]; positive regulation of oxidoreductase activity [GO:0051353]; steroid biosynthetic process [GO:0006694]
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GO - Molecular function (MF):
2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]...
2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]
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GO - Cellular component (CC):
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]...
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]
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FDX1
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Kaplan plot for FDX1 in
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*NOTE: the Kaplan plots were collected from OncoLnc