DegronMD - P10244(MYBL2)

FUNCTION: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.

GO - Biological processes (BP): cellular response to leukemia inhibitory factor [GO:1990830]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA... View more >>

GO - Molecular function (MF): DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding... View more >>

GO - Cellular component (CC): Myb complex [GO:0031523]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
SRGELIPIS	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Myb-related protein B	385:393	More..
RRVALSPVT	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Myb-related protein B	416:424	More..
LTPKST	DEG_SCF_FBW7_1	FBXW7	Myb-related protein B	439:444	More..
LTSTPVCS	DEG_SCF_FBW7_1	FBXW7	Myb-related protein B	473:480	More..
LPQTPHLE	DEG_SCF_FBW7_2	FBXW7	Myb-related protein B	535:542	More..
AATTS	DEG_SPOP_SBC_1	SPOP	Myb-related protein B	247:251	More..

Showing 1 to 6 of 6 entries

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R388W	DO41331	UCEC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8634
p.R417C	TCGA-2W-A8YY	CESC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.8301
p.R417C	TCGA-XK-AAIW	PRAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.8301
p.R393C	DO223732	CESC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8301
p.R393C	DO51407	PRAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8301
p.T440A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.825
p.T440A	ACH-000782	Leukemia	CCLE	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.825
p.T440A	ACH-001735	Leukemia	CCLE	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.825
p.R417H	TCGA-34-5231	LUSC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.8244
p.R393H	DO26772	LUSC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8244
p.L473Q	TCGA-AC-A5XU	BRCA	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.7765
p.S251L	TCGA-AG-A002	READ	TCGA	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7667
p.P250L	DO51259	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7582
p.P421A	DO22926	LIHC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7503
p.R540S	DO229006	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation altering degron motif	0.7427
p.T416M	DO234237	ESAD	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7423
p.R388Q	DO223286	UCEC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7329
p.D538Y	DO20368	KIRC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation altering degron motif	0.7325
p.T441I	NCI-H630	large intestine	COSMIC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.7078
p.S419N	DO48382	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7069

Showing 1 to 20 of 123 entries

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No resistance data available for this Degron.

Kaplan plot for MYBL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBL2

UniProt ID: P10244

Entrez ID: 4605

Protein name: Myb-related protein B (B-Myb) (Myb-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for MYBL2 in