DegronMD - P10244(MYBL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G400C	TCGA-17-Z016	LUAD	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.R417C	TCGA-2W-A8YY	CESC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.8301
p.R417C	TCGA-XK-AAIW	PRAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.8301
p.R417H	TCGA-34-5231	LUSC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.8244
p.D260H	TCGA-37-3792	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.0833
p.S395C	TCGA-38-4626	LUAD	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.D544N	TCGA-3U-A98F	MESO	TCGA	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.2778
p.D434Y	TCGA-64-5774	LUAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0556
p.D434Y	TCGA-64-5774	LUAD	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.1944
p.A419S	TCGA-78-7536	LUAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.6477
p.S435F	TCGA-90-A4ED	LUSC	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.2222
p.S452L	TCGA-A5-A2K3	UCEC	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation blocking phosphorylation signal	0.5556
p.L473Q	TCGA-AC-A5XU	BRCA	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.7765
p.S251L	TCGA-AG-A002	READ	TCGA	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7667
p.P453S	TCGA-AP-A1DR	UCEC	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.0833
p.E469D	TCGA-AP-A1DV	UCEC	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.2222
p.D260Y	TCGA-AX-A2HD	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.0833
p.P445A	TCGA-BC-A10U	LIHC	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.3056
p.A525T	TCGA-BR-4184	STAD	TCGA	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.0556
p.T474K	TCGA-CK-4951	COAD	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.6195
p.R412Q	TCGA-DF-A2KU	UCEC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2222
p.G258C	TCGA-EB-A24D	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1389
p.G258S	TCGA-EO-A22U	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1389
p.P407L	TCGA-ER-A198	SKCM	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.P407L	SIDM01175	Other Sarcomas	GDSC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.P407L	ACH-002309	Sarcoma	CCLE	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.P407L	SW684	soft tissue	COSMIC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.0833
p.S438I	TCGA-ER-A19N	SKCM	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.3056
p.R412W	TCGA-FI-A2D5	UCEC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2222
p.S551Y	TCGA-FS-A1ZM	SKCM	TCGA	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.0833
p.V446L	TCGA-FT-A61P	BLCA	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.2778
p.S454F	TCGA-GU-AATO	BLCA	TCGA	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation blocking phosphorylation signal	0.5
p.E425K	TCGA-H2-A421	THCA	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.3056
p.E425K	TCGA-T2-A6WZ	HNSC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.3056
p.G387S	TCGA-JW-A5VL	CESC	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.5882
p.G387D	TCGA-JW-A5VL	CESC	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.6087
p.V478A	TCGA-N7-A4Y0	UCS	TCGA	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.5825
p.S401C	TCGA-XF-A8HE	BLCA	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1111
p.S419N	DO48382	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7069
p.S430F	DO51893	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.1667
p.S430F	DO51893	BLCA	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.0833
p.S377C	DO49797	BLCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1111
p.V422L	DO44035	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.6765
p.D254E	DO224885	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.S403G	DO228483	BRCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.S403G	DO229010	COCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.S403G	DO229003	COCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.S403G	DO234285	ESAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.S403G	DO229480	LAML	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.L449Q	DO223933	BRCA	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.1944
p.R393C	DO223732	CESC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8301
p.R393C	DO51407	PRAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8301
p.T450K	DO10582	COAD	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.1667
p.R241Q	DO222788	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation blocking phosphorylation signal	0.6111
p.T416M	DO234237	ESAD	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7423
p.D468N	DO233251	GACA	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.1944
p.E401K	DO219067	HNSC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1111
p.E401K	DO39024	THCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1111
p.A529S	DO19693	KIRC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.1667
p.D538Y	DO20368	KIRC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation altering degron motif	0.7325
p.Q484L	DO228203	LICA	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.2222
p.R241L	DO228948	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation blocking phosphorylation signal	0.6111
p.G376V	DO228974	LICA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0833
p.R551L	DO228971	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.0833
p.E244D	DO229037	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.R540S	DO229006	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation altering degron motif	0.7427
p.G378V	DO229006	LICA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1389
p.G530V	DO229008	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.1944
p.P421A	DO22926	LIHC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.7503
p.S403N	DO48701	LIRI	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.0556
p.A395S	DO26414	LUAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.M488I	DO23818	LUAD	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.1111
p.D254H	DO45332	LUAD	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25
p.D410Y	DO24770	LUAD	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.1667
p.P471S	DO23687	LUAD	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.2778
p.P541S	DO25020	LUAD	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation altering degron motif	0.6752
p.S448L	DO224544	LUSC	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.2222
p.S448L	DO231014	LUSC	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.2222
p.L550P	DO26502	LUSC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.1111
p.R393H	DO26772	LUSC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8244
p.S411F	DO45482	LUSC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation blocking ubiquitination signal	0.6389
p.R526H	DO229591	PRAD	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.0833
p.S527Y	DO37731	SKCM	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.1111
p.S414I	DO37452	SKCM	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2778
p.G380D	DO37966	SKCM	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.1944
p.P383L	DO47563	SKCM	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.P383L	SW684	soft tissue	COSMIC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.T381A	DO47563	SKCM	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2222
p.P250L	DO51259	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.7582
p.A239T	DO47717	STAD	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.P426A	DO231326	THCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2778
p.E247D	DO42033	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.6758
p.E532K	DO41020	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.25
p.E532K	DO52412	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.25
p.E532K	DO41524	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.25
p.E532K	DO42793	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.25
p.A478V	DO41020	UCEC	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.6936
p.A478V	DND-41	haematopoietic and lymphoid tissue	COSMIC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation altering degron motif	0.6936
p.R388Q	DO223286	UCEC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.7329
p.E445D	DO43186	UCEC	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.3056
p.D483N	DO41584	UCEC	ICGC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation rewiring degron network	0.25
p.R552Q	DO42608	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.0556
p.S428L	DO43899	UCEC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.2222
p.R551W	DO41235	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.0833
p.P429S	DO43747	UCEC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.1944
p.P429S	DO43747	UCEC	ICGC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation rewiring degron network	0.0556
p.R388W	DO41331	UCEC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation altering degron motif	0.8634
p.A419G	SIDM01119	Other Solid Cancers	GDSC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.6429
p.A419G	ACH-000775	Lung Cancer	CCLE	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.6429
p.A419G	NCI-H727	lung	COSMIC	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation altering degron motif	0.6429
p.A248V	SIDM01570	Ovarian Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.5825
p.A248V	ACH-000324	Ovarian Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.5825
p.T440A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.825
p.T440A	ACH-000782	Leukemia	CCLE	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.825
p.T440A	ACH-001735	Leukemia	CCLE	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.825
p.K528N	ACH-000923	Lymphoma	CCLE	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation blocking ubiquitination signal	0.5833
p.R550C	ACH-000999	Colon/Colorectal Cancer	CCLE	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.1111
p.Q413R	ACH-001414	Bladder Cancer	CCLE	RRVALSPVT	DEG_APCC_DBOX_1	416:424	Mutation rewiring degron network	0.25
p.Y529C	ACH-001719	Ovarian Cancer	CCLE	LPQTPHLE	DEG_SCF_FBW7_2	535:542	Mutation rewiring degron network	0.1667
p.T441I	NCI-H630	large intestine	COSMIC	LTPKST	DEG_SCF_FBW7_1	439:444	Mutation altering degron motif	0.7078
p.T465I	NCI-H630	large intestine	COSMIC	LTSTPVCS	DEG_SCF_FBW7_1	473:480	Mutation blocking phosphorylation signal	0.5556
p.A395G	NCI-H727	lung	COSMIC	SRGELIPIS	DEG_APCC_DBOX_1	385:393	Mutation rewiring degron network	0.2778
p.P260R	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	AATTS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBL2

UniProt ID: P10244

Entrez ID: 4605

Protein name: Myb-related protein B (B-Myb) (Myb-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYBL2 in