DegronMD - P11308(ERG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T32S	TCGA-05-5425	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.K37N	TCGA-23-2084	OV	TCGA	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6918
p.D47N	TCGA-AX-A063	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1111
p.P33S	TCGA-DI-A1BU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.M40I	TCGA-E2-A159	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.3056
p.E27Q	TCGA-G2-A3IE	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1111
p.M33I	DO2808	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.S39G	DO222884	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.8104
p.T25S	DO26270	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation blocking phosphorylation signal	0.5
p.K30N	DO30310	OV	ICGC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation substituting flanking lysine	0.3056
p.P26S	DO42023	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.0833
p.D40N	DO42201	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.3056
p.A42V	SIDM00781	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42V	SIDM00780	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42V	ACH-000967	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42V	ACH-001199	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42V	SNU-C2B	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42T	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42T	ACH-000637	Esophageal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.A42T	KYSE-520	oesophagus	COSMIC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.M26I	NCI-H1355	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.0833
p.A35T	KYSE-520	oesophagus	COSMIC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.7139
p.A35V	SNU-C2B	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.5825

Kaplan plot for ERG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERG

UniProt ID: P11308

Entrez ID: 2078

Protein name: Transcriptional regulator ERG (Transforming protein ERG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERG in