DegronMD - P14780(MMP9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P464H	TCGA-19-5956	GBM	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1389
p.P464H	DO13863	GBM	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1389
p.T466M	TCGA-61-1730	OV	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	TCGA-AG-3909	READ	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	TCGA-J4-AAU2	PRAD	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	TCGA-ZX-AA5X	CESC	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	DO219762	CESC	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	DO31859	OV	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	DO219263	PRAD	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.T466M	DO36578	READ	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.0833
p.R446H	TCGA-A6-5665	COAD	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1389
p.R446H	DO9756	COAD	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1389
p.T462M	TCGA-AA-3818	COAD	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1944
p.T462M	TCGA-JY-A93E	ESCA	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1944
p.T462M	DO7792	COAD	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1944
p.R452Q	TCGA-AP-A0LM	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.R452Q	DO43306	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.R452W	TCGA-OR-A5JK	ACC	TCGA	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.R452W	DO233868	GACA	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.R452W	SIDM01282	Colorectal Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.P464T	DO228916	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1389
p.P454Q	DO228906	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.5924
p.P465L	DO227688	SKCA	ICGC	PPTTT	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1111

Kaplan plot for MMP9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMP9

UniProt ID: P14780

Entrez ID: 4318

Protein name: Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMP9 in