DegronMD - P15173(MYOG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G34A	TCGA-60-2724	LUSC	TCGA	PPGY	ITCH	32:35	Mutation altering degron motif	0.6429
p.G34A	DO26540	LUSC	ICGC	PPGY	ITCH	32:35	Mutation altering degron motif	0.6429
p.H26L	TCGA-78-7155	LUAD	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1667
p.H26L	DO23590	LUAD	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1667
p.E31K	TCGA-AA-3510	COAD	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	TCGA-AG-A002	READ	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	TCGA-F5-6814	READ	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	DO7783	COAD	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	DO36556	READ	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	ACH-002214	Lymphoma	CCLE	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E31K	BC-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.P24H	TCGA-AJ-A3BG	UCEC	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1111
p.P24H	DO42633	UCEC	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1111
p.P44H	TCGA-AX-A2HG	UCEC	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.0833
p.P44H	DO41337	UCEC	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.0833
p.E45K	TCGA-BT-A0YX	BLCA	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.0556
p.E45K	DO516	BLCA	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.0556
p.E45K	DO229395	PRAD	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.0556
p.P24S	TCGA-VQ-A8E2	STAD	TCGA	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1111
p.P24S	DO51758	STAD	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1111
p.T41N	DO229008	LICA	ICGC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.1667
p.R37Q	SIDM00399	Head and Neck Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.R37Q	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.R37Q	SIDM00481	Ovarian Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.R37Q	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.R37Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.2778
p.T38M	SIDM00999	Bladder Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.25
p.T38M	SIDM01619	Endometrial Carcinoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.25
p.T38M	ACH-000973	Bladder Cancer	CCLE	PPGY	ITCH	32:35	Mutation rewiring degron network	0.25
p.T38M	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	32:35	Mutation rewiring degron network	0.25
p.T38M	639-V	urinary tract	COSMIC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.25
p.E36Q	SIDM00312	Plasma Cell Myeloma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056
p.E36Q	SIDM01566	Hodgkin's Lymphoma	GDSC	PPGY	ITCH	32:35	Mutation rewiring degron network	0.3056

Kaplan plot for MYOG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOG

UniProt ID: P15173

Entrez ID: 4656

Protein name: Myogenin (Class C basic helix-loop-helix protein 3) (bHLHc3) (Myogenic factor 4) (Myf-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOG in