DegronMD - P15311(EZR)

EZR

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P480Q	TCGA-A6-5665	COAD	TCGA	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2778
p.P480Q	DO9756	COAD	ICGC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2778
p.P471L	DO233885	GACA	ICGC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471L	SIDM00200	Ewing's Sarcoma	GDSC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471L	SIDM00282	Colorectal Carcinoma	GDSC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471L	SIDM00018	Acute Myeloid Leukemia	GDSC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471L	CW-2	large intestine	COSMIC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471L	EW-12	bone	COSMIC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471L	KO52	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P471Q	DO229028	LICA	ICGC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.2222
p.P472T	DO229037	LICA	ICGC	PPVY	ITCH	475:478	Mutation rewiring degron network	0.25
p.P476S	SIDM00652	Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	475:478	Mutation altering degron motif	0.6752
p.P476S	ACH-000780	Lung Cancer	CCLE	PPVY	ITCH	475:478	Mutation altering degron motif	0.6752
p.P476S	NCI-H1105	lung	COSMIC	PPVY	ITCH	475:478	Mutation altering degron motif	0.6752
p.V477L	ACH-001970	Metastasis	CCLE	PPVY	ITCH	475:478	Mutation altering degron motif	0.5654
p.V477L	ACH-002460	Skin Cancer	CCLE	PPVY	ITCH	475:478	Mutation altering degron motif	0.5654

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*NOTE: the Kaplan plots were collected from OncoLnc