DegronMD - P15529(CD46)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S298G	TCGA-A5-A1OF	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1667
p.S298G	DO42568	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1667
p.K285T	TCGA-DD-A4NF	LIHC	TCGA	PPSST	DEG_SPOP_SBC_1	288:292	Mutation substituting flanking lysine	0.3611
p.K285T	DO44950	LIHC	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation substituting flanking lysine	0.3611
p.L297F	TCGA-DK-A3X1	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1944
p.L297F	DO447	BLCA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1944
p.P288A	TCGA-FR-A726	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6392
p.P288A	DO48665	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6392
p.P293H	DO8778	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.3056
p.P289L	DO50319	ESAD	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6471
p.S298I	DO228974	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1667
p.C283F	DO229022	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1944
p.C283F	DO229045	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1944
p.R288S	DO229006	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7427
p.P279S	DO50880	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.0833
p.Y298H	DO46657	PAAD	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1667
p.L287M	DO232224	PBCA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.3056
p.S291I	DO229245	THCA	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7341
p.P289H	DO41361	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6583

Kaplan plot for CD46 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD46

UniProt ID: P15529

Entrez ID: 4179

Protein name: Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD46 in