DegronMD - P15976(GATA1)

GO - Biological processes (BP): animal organ regeneration [GO:0031100]; basophil differentiation [GO:0030221]; cell-cell signaling [GO:0007267]; cell fate commitment [GO:0045165]; cellular response to cAMP [GO:0071320]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to thyroid hormone stimulus [GO:0097067]; dendritic cell differentiation [GO:0097028]; embryonic hemopoiesis [GO:0035162]; eosinophil differentiation [GO:0030222]; eosinophil fate commitment [GO:0035854]; erythrocyte development [GO:0048821]; erythrocyte differentiation [GO:0030218]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; megakaryocyte differentiation [GO:0030219]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bone mineralization [GO:0030502]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of definitive erythrocyte differentiation [GO:0010724]; regulation of glycoprotein biosynthetic process [GO:0010559]; regulation of primitive erythrocyte differentiation [GO:0010725]; Sertoli cell development [GO:0060009] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T54N	TCGA-05-4427	LUAD	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.T54N	DO23666	LUAD	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.P410Q	TCGA-49-6761	LUAD	TCGA	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1667
p.P410Q	DO24566	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1667
p.T402I	TCGA-A5-A0G1	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.7078
p.T402I	DO42472	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.7078
p.S404N	TCGA-A5-A1OF	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.7069
p.T54I	TCGA-A5-A2K5	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.T54I	DO41379	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.A58V	TCGA-AD-5900	COAD	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0556
p.A58V	DO8514	COAD	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0556
p.T48N	TCGA-AP-A0LI	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.7055
p.T48N	DO43658	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.7055
p.A55T	TCGA-AP-A0LM	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1389
p.A55T	TCGA-OR-A5K4	ACC	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1389
p.A55T	DO43306	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1389
p.P50L	TCGA-BR-4361	STAD	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2778
p.P50L	DO38887	STAD	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2778
p.P401S	TCGA-D3-A51T	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.5641
p.P401S	DO47389	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.5641
p.D42N	TCGA-EE-A2A2	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2778
p.D42N	DO37583	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2778
p.P50Q	TCGA-EE-A2GK	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2778
p.P50Q	DO37738	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2778
p.P410L	TCGA-EK-A2R9	CESC	TCGA	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1667
p.P410L	DO51600	CESC	ICGC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1667
p.P38S	TCGA-EO-A3B0	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.P38S	DO219773	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.A53T	DO225111	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1944
p.P400S	DO222647	MELA	ICGC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation altering degron motif	0.6752
p.T391M	DO232761	PBCA	ICGC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.0833
p.G397R	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.25
p.G397R	ACH-001599	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.25
p.G397R	NCI-H64	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.25
p.T391S	SIDM01445	Gastric Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.0833
p.T391K	SIDM01445	Gastric Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.0833
p.T391K	ACH-000736	Gastric Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.0833
p.P395L	ACH-000662	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	400:404	Mutation rewiring degron network	0.1944

Kaplan plot for GATA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATA1

UniProt ID: P15976

Entrez ID: 2623

Protein name: Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATA1 in