NCK1
UniProt ID: P16333
Entrez ID: 4690
Protein name: Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detecti...
FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.
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GO - Biological processes (BP):
actin filament organization [GO:0007015]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of cell death [GO:0060548]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:19039...
actin filament organization [GO:0007015]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; lamellipodium assembly [GO:0030032]; negative regulation of cell death [GO:0060548]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cap-dependent translational initiation [GO:1903676]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of neuron projection development [GO:0010976]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of cell migration [GO:0030334]; response to other organism [GO:0051707]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; substrate-dependent cell migration, cell extension [GO:0006930]; T cell activation [GO:0042110]
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GO - Molecular function (MF):
cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein-macromolecule adaptor activity...
cadherin binding [GO:0045296]; cytoskeletal anchor activity [GO:0008093]; ephrin receptor binding [GO:0046875]; eukaryotic initiation factor eIF2 binding [GO:0071074]; protein domain specific binding [GO:0019904]; protein kinase inhibitor activity [GO:0004860]; protein-macromolecule adaptor activity [GO:0030674]; receptor tyrosine kinase binding [GO:0030971]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; signaling receptor complex adaptor activity [GO:0030159]
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GO - Cellular component (CC):
cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506]...
cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; ribosome [GO:0005840]; vesicle membrane [GO:0012506]
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NCK1
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*NOTE: the Kaplan plots were collected from OncoLnc