DegronMD - P17098(ZNF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S186P	TCGA-AX-A2HD	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.S186P	DO42608	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.P192Q	TCGA-D3-A1Q3	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1944
p.P192Q	DO47509	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1944
p.P190S	TCGA-EE-A3J5	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.25
p.P190S	DO47331	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.25
p.P188S	TCGA-FW-A3R5	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.3056
p.P188S	DO37406	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.3056
p.N189D	DO222871	BTCA	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2778
p.V183I	DO233902	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7076
p.G197E	DO36969	READ	ICGC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0556
p.L184P	SIDM01198	Burkitt's Lymphoma	GDSC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6471
p.L184P	SIDM00125	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6471
p.I194L	SIDM00043	Head and Neck Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.I194L	PCI-4B	upper aerodigestive tract	COSMIC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.R177T	SIDM00799	Glioblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.R177T	ACH-000558	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.R177T	A172	central nervous system	COSMIC	VLSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667

Kaplan plot for ZNF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF8

UniProt ID: P17098

Entrez ID: 7554

Protein name: Zinc finger protein 8 (Zinc finger protein HF.18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF8 in